Matrix metalloprotease regulation of neuropathic pain
نویسندگان
چکیده
منابع مشابه
The pain matrix and neuropathic pain.
Two articles published in this and a recent edition of Brain (Iadarola et al., 1998; Peyron et al., 1998) raise some issues about what functional imaging studies can teach us about nociceptive and non-nociceptive processing in the brain. Both papers address whether brain structures activated during neuropathic and acute experimental nociceptive pain are different. In Peyron et al.'s paper, the ...
متن کاملACUPUNCTURE AND NEUROPATHIC PAIN About neuropathic pain
Neuropathic pain results from damage to, or dysfunction of, the system that normally signals pain. The International Association for the Study of Pain (IASP 2007) defines neuropathic pain as follows: ‘Pain initiated or caused by a primary lesion or dysfunction in the nervous system. Peripheral neuropathic pain occurs when the lesion or dysfunction affects the peripheral nervous system. Central ...
متن کاملPharmacological Regulation of Neuropathic Pain Driven by Inflammatory Macrophages
Neuropathic pain can have a major effect on quality of life but current therapies are often inadequate. Growing evidence suggests that neuropathic pain induced by nerve damage is caused by chronic inflammation. Upon nerve injury, damaged cells secrete pro-inflammatory molecules that activate cells in the surrounding tissue and recruit circulating leukocytes to the site of injury. Among these, t...
متن کاملRegulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels.
Pain per se may increase anxiety and conversely, anxiety may increase pain. Therefore, a positive feedback loop between anxiety and pain possibly contributes to pain and suffering in some pathophysiological pain conditions, such as that induced by peripheral nerve injury. Recent results indicate that transient receptor channels 4 and 5 (TRPC4/C5) in the amygdala have anxiogenic effects in roden...
متن کاملNeuropathic pain
Neuropathic pain (NP) is defined as ''pain arising as a direct consequence of any lesion or disease affecting the somatosensory system. " [1,2] Although NP may be an idiopathic process reflecting abnormal sensory processing in the peripheral or central nervous system, it more often appears following physical insult or disease affecting the peripheral or central nervous system. It is likely that...
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2009
ISSN: 0165-6147
DOI: 10.1016/j.tips.2009.04.002